Novel GABAergic Circuits Mediating Excitation/Inhibition of Cajal-Retzius Cells in the Developing Hippocampus
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چکیده
منابع مشابه
Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus.
Cajal-Retzius cells are a class of neurons believed to play critical roles during cortical development. However, their network computational functions remain poorly understood. Although work in the neocortex and hippocampus has shown that Cajal-Retzius cells receive predominantly, if not exclusively, spontaneous GABA(A) receptor-mediated input, the cellular sources originating these events rema...
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The marginal zone (MZ) of the prenatal cerebral cortex plays a crucial role in cellular migration and laminar patterning in the developing neocortex and its equivalent in the adult brain - layer I, participates in cortical circuitry integration within the adult neocortex. The MZ/layer I, which has also been called the plexiform layer and cell-poor zone of Meynert, among others, is home to sever...
متن کاملOptogenetic activation of cajal-retzius cells reveals their glutamatergic output and a novel feedforward circuit in the developing mouse hippocampus.
Cajal-Retzius cells orchestrate the development of cortical circuits by secreting the glycoprotein reelin. However, their computational functions are still unknown. In fact, the nature of their postsynaptic targets, major neurotransmitter released, as well as the class of postsynaptic receptors activated by their firing remain unclear. Here, we have addressed these questions by activating Cajal...
متن کاملCajal-Retzius cells
What is a Cajal-Retzius cell? A transient class of neurons found in the surface of the developing cerebral cortex of mammals. They are named after Santiago Ramón y Cajal and Gustaf Retzius, who first described them at the end of the 19th century. These ‘special cells’, as Cajal initially called them, populate the marginal zone of the cortex from early stages of development (Figure 1), and thus ...
متن کاملAmbient GABA constrains the strength of GABAergic synapses at Cajal-Retzius cells in the developing visual cortex.
At early stages of brain development, GABA plays a dual role. It fulfills important trophic functions and provides a major excitatory drive for the immature neuronal network. Here, we investigated whether GABA itself can limit the strength of excitatory GABAergic synapses on Cajal-Retzius (CR) cells in sagittal slices from the mouse visual cortex. (2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2013
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.5680-12.2013